| Aiken Womens Heart Board | Aiken | C | $134K |
| Association of Cancer Center | Charleston | A | $479K |
| Challenge to Conquer Cancer | Greenville | D | $233K |
| Chase After a Cure Inc | Summerville | D | $1,571 |
| Clinical Biotechnology Research Institute at RSFH | Charleston | D | $585K |
| Closing the Gap in Health Care Inc | North Charleston | D | $195K |
| Council on Chiropractic Guidelines and Practice Parameters | Lexington | C | $124K |
| Cure Sanfilippo Foundation | Columbia | C | $2.78M |
| David M Carmines Memorial Fund | Hilton Head | C | $219K |
| Dorn Research Institute Inc | Columbia | B | $487K |
| Drake Rayden Foundation | Simpsonville | D | $42K |
| Dylan Adams Endowment | Hartsville | D | $81K |
| Emily Brown Kocis Celebration of Life Group | Greer | D | $33K |
| Foundation for Pediatric Health | Goose Creek | D | $77K |
| Greenwood Genetic Center Inc | Greenwood | A | $30.86M |
| Joanna Ruth Bell Foundation | Spartanburg | B | $0 |
| Joanne W Charles Memorial Fund | Summerton | A | $18K |
| Living Water Foundation Inc | Prosperity | D | $18K |
| Lowcountry Center for Veterans | Charleston | A | $5.35M |
| Medical University of South Carolina | Charleston | C | $136.66M |
| Melanated Melon | Fort Mill | C | $14K |
| Musc Foundation for Research Development | Charleston | A | $5.64M |
| Phillips-Amick Foundation for Cancer | Greenville | D | $286K |
| RDH12 Fund for Sight | Boiling SPGS | F | $105K |
| Rockers for Knockers Inc | Mount Pleasant | A | $0 |
| Sara's Cure | Charleston | A | $92K |
| Share Our Suzy (Sos) | Columbia | B | $2,060 |
| South Carolina Advocates for Epilepsy | Goose Creek | C | $47K |
| Southeastern Regional Genetics Group Inc | Lancaster | C | $208K |
| The Curemapk8Ip3 Foundation | Fort Mill | C | $2,062 |
| The Hawkins Foundation | Greenville | B | $1.11M |
| The Health and Welfare Foundation | Aiken | D | $20K |
| The Shane Edward Tanzosh Arvc | N Myrtle BCH | D | $50 |
| The Slade Dozier Foundation | MT Pleasant | D | $15K |
| The Technology Accelerator | Kiawah Island | D | $176K |
| TRS Cancer Fighters Inc | N Myrtle BCH | C | $207K |
| Zucker Institute for Applied Neurosciences Inc | Charleston | A | $0 |
Charity Clarity