| A Cure in Sight | Edenton | C | $525K |
| Academy of Clinical Research and Study | Chapel Hill | D | $192K |
| Adam Faulk Tanksley Foundation Inc | Waxhaw | A | $31K |
| Addis Cure Inc | Cornelius | F | $11K |
| Alpha 1 Village Inc | Charlotte | F | $0 |
| American Association of Extracellular Vesicles Inc | Cary | D | $269K |
| American Thrombosis and Hemostasis | Hickory | B | $15.98M |
| As Healthy as Possible | Winston Salem | D | $6,025 |
| Bacterial Locomotion and Signal | Chapel Hill | C | $276K |
| Blue Ridge Institute for Medical Research | Horse Shoe | C | $6,000 |
| Brandon Battle Foundation Inc | Charlotte | D | $2,053 |
| Cancer Active Inc | Asheville | D | $135K |
| Cancer Biology Training Consortium | Raleigh | C | $390K |
| Cancer Genomics Consortium | Fletcher | A | $512K |
| Cancer Patient Advocate Foundation | Mooresville | F | $0 |
| Carolina Ear Research Institute | Raleigh | A | $331K |
| Celebrate for Good Inc | Raleigh | C | $2,057 |
| Chapel Hill Breast Cancer Foundation | Chapel Hill | D | $93K |
| Charlesson Foundation | Lewisville | D | $479K |
| Cherokee Cancer Support Group Inc | Cherokee | C | $75K |
| Childress Institute for Pediatric Trauma | Winston Salem | A | $0 |
| Chordoma Foundation | Durham | C | $13.41M |
| Columbus Children's Foundation | Chapel Hill | C | $110K |
| Confederacion Americana de Urologia | Winston Salem | F | $308K |
| CPM Billfish Tournament | Morehead City | B | $160K |
| Dhit Global | Carrboro | D | $694K |
| Duke Medicine Global Support Corporation | Durham | D | $207K |
| Friends for an Earlier Breast Cancer Test Inc | Greensboro | B | $527K |
| Friends of Faith & Hope Cancer Awareness Inc | Greensboro | F | $0 |
| Glioblastoma Foundation Inc | Durham | B | $2.06M |
| Health Enhancement Research | Raleigh | C | $718K |
| Health Research Alliance Inc | Raleigh | B | $801K |
| International Cancer Care and Research Excellence Foundation Inc | Durham | C | $101K |
| International Cannabinoid Research | Winston Salem | C | $225K |
| International Neurosurgery Education and | Raleigh | D | $232K |
| International Society for Cardiovascular | Chapel Hill | D | $7 |
| Jim Catfish Hunter Als Foundation | Hertford | F | $75K |
| Kios Institute Inc | Durham | F | $0 |
| Live Like Madison Inc | Laurinburg | D | $232K |
| LVH Als Foundation | Winston Salem | C | $15K |
| Lydias Legacy Incorporated | Charlotte | F | $3 |
| Megs Smile Foundation Inc | Holly Springs | C | $216K |
| Neuroimmune North Carolina | Raleigh | C | $397K |
| No One Left Alone | Charlotte | D | $247K |
| North Carolina Association for | Raleigh | A | $472K |
| North Carolina Pediatric Society Inc | Raleigh | C | $792K |
| North Carolina Rare Disease | Durham | D | $25K |
| Not Defined by FND | Wilmington | C | $4,046 |
| Oms Educational Fund of | Denver | C | $43K |
| Open Humans Foundation | Sanford | D | $59K |
| Opti Health Research Institute | Mooresville | C | $86K |
| Orthocarolina Research Institute Inc | Charlotte | C | $2.64M |
| Parkinson Association of | Charlotte | C | $368K |
| Pediatric Brain Tumor Foundation of the United States Inc | Winston Salem | C | $5.85M |
| Pete Keel Foundation | Conover | B | $20K |
| Pioneers for Quality | Lawndale | C | $123K |
| Plasminogen Deficiency Foundation | Chapel Hill | D | $8,640 |
| Pounding for Parker Foundation | Cornelius | B | $45K |
| Project DS Inc | Morrisville | D | $1.83M |
| Raines' Army Inc | Edenton | F | $91K |
| Rare Cancer Research Foundation | Durham | B | $446K |
| Readdi Inc | Durham | C | $624K |
| Rebuild Medicine Inc | Mooresville | D | $456K |
| Reelin' for Research Inc | Greensboro | C | $989K |
| Reese Ward Foundation Inc | Cary | C | $340K |
| Regenmed Development Organization | Winstonsalem | D | $4.13M |
| Renu Life Extended | Goldsboro | C | $3.10M |
| Rome Foundation | Raleigh | B | $3.49M |
| Rudy S Foundation Inc | Holly Springs | F | $40K |
| Salisbury Foundation for Research and Education Inc | Salisbury | C | $440K |
| She Rocks Inc | Greensboro | C | $201K |
| Society for Translational Oncology | Durham | C | $289K |
| South Robeson Medical Dev Corp | Fairmont | C | $106K |
| Spirovation Inc | Chapel Hill | C | $721K |
| Studies in Philology Incorporated | Chapel Hill | D | $330K |
| Taylor Anne Foundation | Cary | D | $66K |
| Teamcbc Inc | Fayetteville | A | $32K |
| The Carolina Headache Foundation | Durham | C | $9,334 |
| The Champ Foundation | Durham | C | $74K |
| The Ella Foard Foundation for Rett | Charlotte | F | $90K |
| The North Carolina Rheumatology | Wilmington | C | $365K |
| The Paula Takacs Foundation for Sarcoma Research | Charlotte | C | $676K |
| The Pearl Psychedelic Institute | Waynesville | C | $536K |
| The Pediatric Cardiac Intensive Care | Raleigh | C | $10 |
| The V Foundation | Cary | B | $61.64M |
| Triangle Global Health Consortium | RTP | C | $178K |
| Voa Foundation | Durham | D | $183K |
| Wplab Inc | Durham | C | $97K |
| York Cross of Honour Medical Research Foundation | Denton | D | $109K |
Charity Clarity